Clifford The Tutor

Welcome (summary)

5.1 What is a calcium signal?

5.1.1a Calcium signal overview

5.1.1b Calcium signal overview

5.1.2a Distribution of calcium in the cell

5.1.2b Distribution of calcium in the cell

5.2 Calcium entry

5.2.1 Transporters involved in calcium entry

5.2.1b Transporters involved in calcium entry

5.2.2 Conformational coupling

5.2.2b Conformational coupling

5.2.3 Calcium induced calcium release

5.2.3b Calcium induced calcium release

5.2.4 IP3-dependent calcium induced calcium release

5.2.4b IP3-dependent calcium induced calcium release

5.3 Calcium exit

5.3.1 Transporters involved in calcium exit

5.3.1b Transporters involved in calcium exit

5.3.2 Digoxin

5.3.2b Digoxin

5.4 Cellular response to calcium signal

5.4.1 Calmoldulin

5.4.1b Calmodulin

5.4.2 CAM kinases

5.4.2b CAM kinases

Outline

6.1 Introduction to osmoregulation, volume regulation and pH regulation

6.1.1 What is homeostasis?

6.1.1b What is homeostasis?

6.1.2 Pump-leak model of osmoregulation

6.1.2b Pump-leak model of osmoregulation

6.2 Osmoregulation and volume regulation

6.2.1 Regulatory volume decrease

6.2.1b Regulatory volume decrease

6.2.2 Regulatory volume increase

6.2.2b Regulatory volume increase

6.3 pH regulation

6.3b pH regulation

Outline

7.1 Cytoskeleton overview

7.1.1 What is a cytoskeleton?

7.1.2 Actin Filament

7.1.3 Microtubules

7.1.4 Intermediate filament

7.2 Polymerization and depolymerization

7.2.1 Stages in the formation of a cytoskeleton polymer

7.2.2 Centrosome

7.2.3 Dynamic instability and GTP cap

7.2.4 Threadmilling

7.2.5 Stability of the cytoskeleton

7.2.6 Motor proteins

7.3 Muscle contraction

7.3.1 Muscle contraction in skeletal muscles

7.3.2 Muscle contraction in smooth muscles

7.4 Movement in non-muscle cells

7.4.1 Cilia and Flagella

7.4.2 Crawling

7.5 Why is intermediate filament so fucking weird?

7.6 Diseases related to the cytoskeleton

Outline

9.1 Cell junctions

9.1.1 What are cell junctions?

9.1.2 Multiadhesive matrix proteins

9.2 Anchoring junctions

9.2.1 Cell-cell anchoring junctions

9.2.2 Cell-ECM anchoring junctions

9.3 CAMs

9.3.1 Integrins

9.3.2 Cadherins

9.3.3 IG superfamily

9.3.4 Selectins

9.4 Extravasation

9.5 Tight junctions

9.6 Gap junctions